pleiotropy
Sign in to saveAlso known as pleiotropism, genetic pleiotropy
thumb|Simple genotype–phenotype map that only shows additive pleiotropy effects. G1, G2, and G3 are different genes that contribute to phenotypic traits P1, P2, and P3.
Research
10,873 papers- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020
- What Is Antagonistic Pleiotropy?Biochemistry. Biokhimiia · 2019
- Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.Biological psychiatry · 2021
- A global overview of pleiotropy and genetic architecture in complex traits.Nature genetics · 2019
- Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.Nature genetics · 2018
via PubMed
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Encyclopedic overview
32 sectionsContents
- History
- Mechanism
- Biological pleiotropy
- Single-gene pleiotropy
- Multigene regulatory pleiotropy
- Mediated pleiotropy
- Spurious pleiotropy
- Other
- Polygenicity-induced horizontal pleiotropy
- Network pleiotropy
- Polygenic risk scores and pleiotropy in complex traits
- Models for the origin
- Evolution
- Antagonistic pleiotropy
- Examples
- Human
- Albinism
- Phenylketonuria (PKU)
- Sickle cell anemia
- Marfan syndrome
- Pain susceptibility
- Animals
- Chickens
- Pleiotropy in psychiatry
- Autism and schizophrenia
- Model organisms
- "Mini-muscle" allele
- Cellular functions and DNA repair
- DNA repair proteins
- See also
- References
- External links
thumb|Simple genotype–phenotype map that only shows additive pleiotropy effects. G1, G2, and G3 are different genes that contribute to phenotypic traits P1, P2, and P3.
Pleiotropy () is a condition in which a single gene or genetic variant influences multiple phenotypic traits. A gene that has such multiple effects is referred to as a pleiotropic gene. Mutations in pleiotropic genes can affect several traits simultaneously, often because the gene product is used in various cells and affects different biological targets through shared signaling pathways.
Excerpted from Wikipedia’s “pleiotropy” article, available under the CC BY-SA 4.0 licence.