PLS1

Also known as Fimbrin, plastin 1, DFNA76

Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Fimbrin is an actin cross-linking protein important in the formation of filopodia.

Gene data

PLS1

Name: plastin 1
Type: protein-coding
Position: 142,595,644–142,713,869 (+)
Aliases: DFNA76
Ensembl: ENSG00000120756
RefSeq RNA: NM_001145319.2, NM_001172312.2, NM_002670.3, XM_006713660.4, XM_011512900.3
RefSeq protein: NP_001138791.1, NP_001165783.1, NP_002661.2, XP_006713723.1, XP_011511202.1

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010].

Pathways

Sensory processing of sound Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Sensory Perception

via MyGene.info

Gene · Ensembl

plastin 1

Symbol: PLS1
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:142,595,644-142,713,869
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: PDB 1pxy EBI.jpg

Show 5 more facts

HomoloGene ID: 68270
exact match: identifiers.org/ncbigene/5357
genomic end: 142432506
genomic start: 142596393
cytogenetic location: 3q23

Sources (6)

via Wikidata · CC0

~3 min read

Article

4 sections

Contents

Structure
Function
References
Further reading

Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Fimbrin is an actin cross-linking protein important in the formation of filopodia.

== Structure ==