polidocanol

Also known as Polydocanol, C12E9, Lauromacrogol, PEG-9 lauryl alcohol, Dodecylpolyethyleneglycolether, Laureth 9, Hydroxyl polyethoxy dodecane

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin. It has also been used to treat varicose veins, hemangiomas, and vascular malformations. It is formed by the ethoxylation of dodecanol.

Chemical data

Formula: C30H62O10
Molecular weight: 582.8 g/mol
IUPAC name: 2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
SMILES: CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChIKey: ONJQDTZCDSESIW-UHFFFAOYSA-N
XLogP: 3.9
Polar surface area: 103 Å²
H-bond donors: 1
H-bond acceptors: 10
Formal charge: 0

via PubChem

Research

1,752 papers

Skin hyperpigmentation after sclerotherapy with polidocanol: A systematic review.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023
Polidocanol: A Review of Off-Label Dermatologic Uses.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2022
Comparative effectiveness of non-compounded polidocanol 1% endovenous microfoam (Varithena) ablation versus endovenous thermal ablation utilizing a systematic review and network meta-analysis.Journal of vascular surgery. Venous and lymphatic disorders · 2024
Redefining hemorrhoid therapy with endoscopic polidocanol foam sclerobanding.World journal of gastroenterology · 2024
Polidocanol Sclerotherapy in Pyogenic Granulomas.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2022

via PubMed

Wikidata facts

Mass: 582.4342981839998
Has use: medication

Show 2 more facts

chemical formula: C₃₀H₆₂O₁₀
canonical SMILES: CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

Sources (3)

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~1 min read

Encyclopedic overview

2 sections

Contents

Sclerotherapy
References

==Sclerotherapy== Polidocanol is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol and Varithena. Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

Excerpted from Wikipedia’s “polidocanol” article, available under the CC BY-SA 4.0 licence.

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