prednisolone

Also known as DELTA.1-Cortisol, Orapred®, Pediapred®, 1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione, 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol, 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene, metacortandralone, Delta(1)-dehydrocortisol

alt=3D space-filling model of Prednisolone under physiological conditions (pH 7.4) and in ALPB solvent Wetoctanol.|thumb|3D space-filling model of prednisolone under physiological conditions (pH 7.4) and in a solvent model

OverviewAI-generated

Prednisolone is a chemical compound with the formula C₂₁H₂₈O₅. Its molecular mass is listed as 360.194, while its weight is recorded as 360.4. The compound has a defined daily dose of 10.

Chemical properties include an xlogp value of 1.6 and a topological polar surface area of 94.8. The molecule contains three hydrogen bond donors and five hydrogen bond acceptors, with a charge of 0.

Prednisolone is referenced by 818 other encyclopedia articles. A search for the term yields a count of 73175 entries in the PubMed database.

Synthesized by Vinony from 19 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Drug.image: Prednisolone-2D-skeletal.svg
Drug.image_class: skin-invert-image
Drug.image2: Prednisolone-from-xtal-3D-bs-17.png
Drug.image_class2: bg-transparent
Drug.tradename: Sterane, others
Drug.MedlinePlus: a615042
Drug.DailyMedID: Prednisolone
Drug.pregnancy_AU: A
Drug.routes_of_administration: By mouth, intravenous, topical, ophthalmic
Drug.class: Glucocorticoid
Drug.ATC_prefix: A07
Drug.ATC_suffix: EA01
Drug.ATC_supplemental: , , , , , , , , , , , , , , , , , , ,
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.legal_status: Rx-only
Drug.elimination_half life: 2–3.5 hours
Drug.excretion: urine

via Wikipedia infobox

Chemical data

Formula: C21H28O5
Molecular weight: 360.4 g/mol
IUPAC name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O
InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N
XLogP: 1.6
Polar surface area: 94.8 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

73,175 papers

Prednisolone.Journal of the American Pharmaceutical Association · 1976
PREDNISOLONE acetate.Journal of the American Medical Association · 1958
The bioavailability and therapeutic effectiveness of prednisolone acetate vs. prednisolone sodium phosphate: a 20-year review.The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc · 1991
[Study on the colon specific delivery of prednisolone using chitosan capsules].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 2007
PREDNISOLONE butylacetate.Journal of the American Medical Association · 1958

via PubMed

~15 min read

Encyclopedic overview

21 sections

Contents

Medical uses
Systemic use
Topical use
Adverse effects
Pregnancy and breastfeeding
Local adverse effects in the eye
Pharmacology
Pharmacodynamics
Pharmacokinetics
Prednisone
Chemistry
Interactions
Special populations
Children
Pregnancy and breastfeeding
Society and culture
Dosage forms
Athletics
Veterinary uses
References
External links

Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, electrolyte imbalances, and skin conditions. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, multiple sclerosis, and phimosis. It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops.

Excerpted from Wikipedia’s “prednisolone” article, available under the CC BY-SA 4.0 licence.