POLR2E
Sign in to saveAlso known as RPABC1, RPB5, XAP4, hRPB25, hsRPB5, polymerase (RNA) II subunit E, RNA polymerase II subunit E, RNA polymerase II, I and III subunit E
DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.
Gene data
POLR2E- Name
- RNA polymerase II, I and III subunit E
- Type
- protein-coding
- Position
- 1,085,104–1,095,389 (−)
- Aliases
- RPABC1, RPB5, XAP4, hRPB25, hsRPB5
- Ensembl
- ENSG00000099817
- RefSeq RNA
- NM_001316323.2, NM_001316324.2, NM_002695.5, XM_011528070.4, XM_017026883.3
- RefSeq protein
- NP_001303252.1, NP_001303253.1, NP_002686.3, XP_011526372.1, XP_016882372.1
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2018
- exact match
- identifiers.org/ncbigene/5434
- genomic end
- 1095598
- genomic start
- 1086574
- cytogenetic location
- 19p13.3
Sources (4)
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- Further reading
DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.