POLR2H

Also known as RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H

DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

Gene data

POLR2H

Name: RNA polymerase II, I and III subunit H
Type: protein-coding
Position: 184,360,856–184,368,596 (+)
Aliases: RPABC3, RPB17, RPB8
Ensembl: ENSG00000163882
RefSeq RNA: NM_001278698.2, NM_001278699.3, NM_001278700.2, NM_001278714.2, NM_001278715.2
RefSeq protein: NP_001265627.1, NP_001265628.1, NP_001265629.1, NP_001265643.1, NP_001265644.1

The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

DNA-templated transcription transcription initiation at RNA polymerase I promoter transcription elongation by RNA polymerase I termination of RNA polymerase I transcription transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter transcription elongation by RNA polymerase II transcription by RNA polymerase III

Molecular function

single-stranded DNA binding DNA-directed RNA polymerase activity DNA-directed RNA polymerase activity

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm RNA polymerase II, core complex RNA polymerase II, core complex RNA polymerase III complex

Pathways

RNA polymerase - Homo sapiens (human)Cytosolic DNA-sensing pathway - Homo sapiens (human)Huntington disease - Homo sapiens (human)Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Signaling by FGFR in disease Developmental Biology Telomere Maintenance Signal Transduction HIV Life Cycle

via MyGene.info

Wikidata facts

Image: Protein POLR2H PDB 2f3i.png

Show 5 more facts

HomoloGene ID: 4540
exact match: identifiers.org/ncbigene/5437
genomic end: 184086384
genomic start: 184079506
cytogenetic location: 3q27.1

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DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.