POSTN
Sign in to saveAlso known as OSF-2, OSF2, PDLPOSTN, PN, periostin
Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a protein that in humans is encoded by the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.
Gene data
POSTN- Name
- periostin
- Type
- protein-coding
- Position
- 37,562,582–37,598,855 (−)
- Aliases
- OSF-2, OSF2, PDLPOSTN, PN
- Ensembl
- ENSG00000133110
- RefSeq RNA
- NM_001135934.2, NM_001135935.2, NM_001135936.2, NM_001286665.2, NM_001286666.2
- RefSeq protein
- NP_001129406.1, NP_001129407.1, NP_001129408.1, NP_001273594.1, NP_001273595.1
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
periostin
- Symbol
- POSTN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:37,562,582-37,598,855
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~7 min read
Encyclopedic overview
8 sectionsContents
- Function
- Clinical significance
- In valvular heart disease
- In tissue regeneration and healing
- In asthma
- In cancer
- References
- Further reading
Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a protein that in humans is encoded by the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.
Periostin is a gla domain vitamin K dependent factor.
Excerpted from Wikipedia’s “POSTN” article, available under the CC BY-SA 4.0 licence.