POU2AF1
Sign in to saveAlso known as BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene. The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1. BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36. The expression of BOB1 has proven useful for identifying certain lymphomas as
Gene data
POU2AF1- Name
- POU class 2 homeobox associating factor 1
- Type
- protein-coding
- Position
- 111,352,255–111,455,630 (−)
- Aliases
- BOB1, OBF-1, OBF1, OCAB
- Ensembl
- ENSG00000110777
- RefSeq RNA
- NM_006235.3, XM_005271593.3, XM_006718859.2, XM_006718860.5, XM_017017932.2
- RefSeq protein
- NP_006226.2, XP_005271650.1, XP_006718922.1, XP_006718923.1, XP_016873421.1
Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
POU class 2 homeobox associating factor 1
- Symbol
- POU2AF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:111,352,255-111,455,630
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein POU2AF1 PDB 1cqt.png
Show 5 more facts
- HomoloGene ID
- 4543
- exact match
- identifiers.org/ncbigene/5450
- genomic end
- 111326355
- genomic start
- 111352255
- cytogenetic location
- 11q23.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- See also
- References
- Further reading
POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene. The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1. BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36. The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas, as exemplified in studies which use BOB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.
== Interactions ==