POU2F1
Sign in to saveAlso known as OCT1, OTF1, oct-1B, POU class 2 homeobox 1, Oct1Z
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
Gene data
POU2F1- Name
- POU class 2 homeobox 1
- Type
- protein-coding
- Position
- 167,220,855–167,427,345 (+)
- Aliases
- OCT1, OTF1, Oct1Z, oct-1B
- Ensembl
- ENSG00000143190
- RefSeq RNA
- NM_001198783.2, NM_001198786.2, NM_001365848.1, NM_001365849.1, NM_002697.4
- RefSeq protein
- NP_001185712.1, NP_001185715.1, NP_001352777.1, NP_001352778.1, NP_002688.3
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
POU class 2 homeobox 1
- Symbol
- POU2F1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:167,220,855-167,427,345
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
840 papers- The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity.Oncogene · 2022
- POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
- POU2F1 inhibits miR-29b1/a cluster-mediated suppression of PIK3R1 and PIK3R3 expression to regulate gastric cancer cell invasion and migration.Chinese medical journal · 2025
- The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2020
- Characterization of POU2F1 Gene and Its Potential Impact on the Expression of Genes Involved in Fur Color Formation in Rex Rabbit.Genes · 2020
via PubMed
Wikidata facts
- Instance of
- gene
- Image
- Protein POU2F1 PDB 1cqt.png
Show 7 more facts
- HomoloGene ID
- 37658
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5451
- genomic end
- 167396582
- genomic start
- 167220876
- chromosome
- human chromosome 1
- cytogenetic location
- 1q24.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
== Interactions ==
Excerpted from Wikipedia’s “POU2F1” article, available under the CC BY-SA 4.0 licence.