PTPRF
Sign in to saveAlso known as LAR, BNAH2, protein tyrosine phosphatase, receptor type F, protein tyrosine phosphatase receptor type F
Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene.
Gene data
PTPRF- Name
- protein tyrosine phosphatase receptor type F
- Type
- protein-coding
- Position
- 43,525,086–43,626,579 (+)
- Aliases
- BNAH2, LAR
- Ensembl
- ENSG00000142949
- RefSeq RNA
- NM_001329137.2, NM_001329138.2, NM_001329139.2, NM_001329140.2, NM_002840.5
- RefSeq protein
- NP_001316066.1, NP_001316067.1, NP_001316068.1, NP_001316069.1, NP_002831.2
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein tyrosine phosphatase receptor type F
- Symbol
- PTPRF
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:43,525,086-43,626,579
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PTPRF PDB 1lar.png
Show 8 more facts
- HomoloGene ID
- 20623
- genetic association
- ALS
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5792
- genomic end
- 44089343
- genomic start
- 43990858
- chromosome
- human chromosome 1
- cytogenetic location
- 1p34.2
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig-like domains similar to those of the neural cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Excerpted from Wikipedia’s “PTPRF” article, available under the CC BY-SA 4.0 licence.