PPIB
Sign in to saveAlso known as CYP-S1, CYPB, HEL-S-39, OI9, SCYLP, peptidylprolyl isomerase B, B
gène de l'espèce Homo sapiens
Gene data
PPIB- Name
- peptidylprolyl isomerase B
- Type
- protein-coding
- Position
- 64,155,740–64,163,159 (−)
- Aliases
- CYP-S1, CYPB, HEL-S-39, OI9, SCYLP
- Ensembl
- ENSG00000166794
- RefSeq RNA
- NM_000942.5
- RefSeq protein
- NP_000933.1
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
peptidylprolyl isomerase B
- Symbol
- PPIB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:64,155,740-64,163,159
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PPIB PDB 1cyn.png
Show 9 more facts
- HomoloGene ID
- 726
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5479
- genomic end
- 64163134
- genomic start
- 64155740
- chromosome
- human chromosome 15
- cytogenetic location
- 15q22.31
- expressed in
- pericardium
- Commons category
- Peptidyl-prolyl cis-trans isomerase B
Sources (3)
via Wikidata · CC0
Article · Français
La cyclophiline B est une protéine appartenant à la famille des cyclophilines ayant une activité de Peptidyl prolyl isomérase. Son gène est le PPIB situé sur le chromosome 15 humain. Il est exprimé dans tous les tissus et présente une homologie avec la cyclophiline A d'environ 65%.
Abstract from DBpedia / Wikipedia · CC BY-SA