CXCL7
Sign in to saveAlso known as neutrophil-activating peptide 2, CXC chemokine ligand 7, MDGF, leukocyte-derived growth factor, small inducible cytokine B7, C-X-C motif chemokine 7, platelet basic protein, thrombocidin 1
Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.
Protein · UniProt
Platelet basic protein
- Gene
- PPBP
- Organism
- Homo sapiens (Human)
- Length
- 128 aa
- Molecular mass
- 13,894 Da
- Evidence
- 1: Evidence at protein level
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitiz…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
7 registered- PHASE2COMPLETEDRAPA-201 T Cell Therapy for Relapsed, Refractory Multiple MyelomaRapa Therapeutics LLC · NCT04176380
- PHASE1/PHASE2TERMINATEDTh1/Tc1 Immunotherapy Following Stem Cell Transplantation in Multiple MyelomaNational Cancer Institute (NCI) · NCT01239368
- PHASE1/PHASE2RECRUITINGRAPA-201 Therapy of Solid TumorsRapa Therapeutics LLC · NCT05144698
- PHASE1COMPLETEDStem Cell Transplant With Th2/Tc2 Cells to Treat Advanced Breast CancerNational Cancer Institute (NCI) · NCT00079625
- PHASE2NOT_YET_RECRUITINGPhase 2b of RAPA-201 Cell Therapy in Post-PD-(L)-1 MelanomaRapa Therapeutics LLC · NCT06708455
- NACOMPLETEDSunitinib Malate in Treating Patients With Kidney CancerCentre Antoine Lacassagne · NCT00943839
Wikidata facts
- Instance of
- protein
Show 3 more facts
- molecular function
- protein binding
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P02775
Sources (4)
via Wikidata · CC0
Article · 中文
趋化因子CXCL7（英語：Chemokine (C-X-C motif) ligand 7，CXCL7）是一个人类基因。其编码的蛋白质为趋化因子（C-X-C基序）配体7 Chemokine (C-X-C motif) ligand，是一种CXC趋化因子类细胞因子，其蛋白异型体为β-血小板球蛋白或原血小板碱性蛋白（英語：Pro-Platelet basic protein，PPBP）。 这种蛋白在血小板活化时被大量释放 ，能刺激多种过程，包括有丝分裂、细胞外基质的合成、和纤溶酶原激活物的合成。
Abstract from DBpedia / Wikipedia · CC BY-SA