IL1RN

Name

interleukin 1 receptor antagonist

Type

protein-coding

Position

113,099,315–113,134,016 (+)

Aliases

CRMO2, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4

Ensembl

ENSG00000136689

RefSeq RNA

NM_000577.5, NM_001318914.2, NM_001379360.1, NM_173841.3, NM_173842.3

RefSeq protein

NP_000568.1, NP_001305843.1, NP_001366289.1, NP_776213.1, NP_776214.1

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020].

via MyGene.info

Gene · Ensembl

interleukin 1 receptor antagonist

Symbol

IL1RN

Biotype

Protein coding

Organism

Homo sapiens

Location

2:113,099,315-113,134,016

Strand

Forward (+)

Assembly

GRCh38