PTPRO

Name

protein tyrosine phosphatase receptor type O

Type

protein-coding

Position

15,322,257–15,602,175 (+)

Aliases

GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O

Ensembl

ENSG00000151490

RefSeq RNA

NM_002848.4, NM_030667.3, NM_030668.3, NM_030669.3, NM_030670.3

RefSeq protein

NP_002839.1, NP_109592.1, NP_109593.1, NP_109594.1, NP_109595.1

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011].

via MyGene.info

Gene · Ensembl

protein tyrosine phosphatase receptor type O

Symbol

PTPRO

Biotype

Protein coding

Organism

Homo sapiens

Location

12:15,322,257-15,602,175

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein PTPRO PDB 2g59.png

via Wikidata · CC0