Structure via PubChem · Public domain (PubChem)
pirazinamide
Sign in to saveAlso known as Zinamide®, PZA, Pyrazine carboxamide, Pyrazineamide, Pirazinamida, Pyrazinamidum, Pyrazinamide
farmaco
Chemical data
- Formula
- C5H5N3O
- Molecular weight
- 123.11 g/mol
- IUPAC name
- pyrazine-2-carboxamide
- SMILES
- C1=CN=C(C=N1)C(=O)N
- InChIKey
- IPEHBUMCGVEMRF-UHFFFAOYSA-N
- XLogP
- -0.6
- Polar surface area
- 68.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1971
- Admin. routes
- oral
- Indications
- pulmonary tuberculosis, AIDS, osteomyelitis, multidrug-resistant tuberculosis
via ChEMBL · EBI
Research
6,571 papers- Pyrazinamide.Tuberculosis (Edinburgh, Scotland) · 2008
- Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial.American journal of respiratory and critical care medicine · 2024
- Pyrazinamide resistance in rifampicin discordant tuberculosis.PloS one · 2022
- Anti-Tubercular Activity of Pyrazinamide Conjugates: Synthesis and Structure-Activity Relationship Studies.Mini reviews in medicinal chemistry · 2023
- Pyrazinamide may possess cardioprotective properties.The Journal of antibiotics · 2019
via PubMed
Wikidata facts
- Mass
- 123.043
- Has use
- medication
Show 10 more facts
- chemical formula
- C₅H₅N₃O
- melting point
- 190
- pKa
- 0.5
- canonical SMILES
- C1=CN=C(C=N1)C(=O)N
- World Health Organisation international non-proprietary name
- pyrazinamide
- defined daily dose
- 1.5
- medical condition treated
- tuberculosis
- Commons category
- Pyrazinamide
- subject has role
- bactericide
- MCN code
- 2933.99.11
Sources (6)
via Wikidata · CC0
Article · Italiano
La pirazinamide è un farmaco di prima scelta nella cura della tubercolosi (altri farmaci attivi sono la rifampicina e l'etambutolo). Il farmaco è altamente batteriostatico, ma può essere anche battericida per i batteri tubercolari che si replicano attivamente.
Abstract from DBpedia / Wikipedia · CC BY-SA