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GeneQ18031020· pop 6· linked from 21 articles

Also known as RAD52 homolog, DNA repair protein

RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene.

Gene data

RAD52
Name
RAD52 DNA repair protein
Type
protein-coding
Position
910,870–990,053 (−)
RefSeq RNA
NM_001297419.1, NM_001297420.1, NM_001297421.2, NM_001297422.2, NM_134422.1
RefSeq protein
NP_001284348.1, NP_001284349.1, NP_001284350.1, NP_001284351.1, NP_602296.2

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014].

via MyGene.info

Gene · Ensembl

RAD52 DNA repair protein

Symbol
RAD52
Biotype
Protein coding
Organism
Homo sapiens
Location
12:910,870-990,053
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein RAD52 PDB 1h2i.png
Show 8 more facts
HomoloGene ID
31118
genetic association
lung cancer
found in taxon
Homo sapiens
genomic end
1099219
genomic start
911736
cytogenetic location
12p13.33
Sources (7)

via Wikidata · CC0

~7 min read

Encyclopedic overview

7 sections
Contents
  • Function
  • Role in DNA recombination repair
  • microRNAs and cancer risk
  • Interactions
  • Intragenic complementation
  • References
  • Further reading

RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene.

== Function ==

Excerpted from Wikipedia’s “RAD52” article, available under the CC BY-SA 4.0 licence.

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