RAD51 recombinase
Sign in to saveAlso known as RecA-like protein, DNA repair protein RAD51 homolog 1, BRCA1/BRCA2-containing complex, subunit 5, RecA, E. coli, homolog of, RAD51 homolog A, RAD51, recombination protein A
DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA, and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to humans.
Protein · UniProt
DNA repair protein RAD51 homolog 1
- Gene
- RAD51
- Organism
- Homo sapiens (Human)
- Length
- 339 aa
- Molecular mass
- 36,966 Da
- Evidence
- 1: Evidence at protein level
Homologous DNA recombinase that catalyzes strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:12205100, PubMed:12442171, PubMed:15937124, PubMed:17515904, PubMed:17515903, PubMed:18417535, PubMed:19303847, PubMed:20231364, PubMed:20348101, PubMed:22325354, PubMed:23509288, PubMed:23754376, PubMed:24141787, PubMed:26681308, PubMed:27941124, PubMed:28575658, PubMed:32640219, PubMed:37499663, PubMed:38509361, PubMed:7988572). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology s…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- chromosome
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/Q06609
via Wikidata · CC0
~14 min read
Encyclopedic overview
15 sectionsContents
- Variants
- Family
- Function
- ''RAD51'' expression in cancer
- Role in double-strand break repair
- Meiosis
- Chemotherapy and aging
- MicroRNA control of ''RAD51'' expression
- Pathology
- Cancer
- Fanconi anemia
- Congenital mirror movements
- Interactions
- References
- External links
DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA, and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to humans.
The name RAD51 derives from radiation sensitive protein 51.
Excerpted from Wikipedia’s “RAD51 recombinase” article, available under the CC BY-SA 4.0 licence.