retinoschisis
Retinoschisis is an eye disease characterized by the abnormal splitting of the retina's neurosensory layers, usually in the outer plexiform layer. Retinoschisis can be divided into degenerative forms which are very common and almost exclusively involve the peripheral retina and hereditary forms which are rare and involve the central retina and sometimes the peripheral retina. The degenerative forms are asymptomatic and involve the peripheral retina only and do not affect the visual acuity. Some rarer forms result in a loss of vision in the corresponding visual field.
Key facts
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- Retinoschisis
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- This condition is usually inherited in an X-linked recessive manner.
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- Ophthalmology
via Wikipedia infobox
Research
2,148 papers- X-Linked Retinoschisis.Cold Spring Harbor perspectives in medicine · 2023
- Retinoschisis: splitting hairs on retinal splitting.Clinical & experimental optometry · 2020
- X-Linked Juvenile Retinoschisis.Advances in experimental medicine and biology · 2025
- [Papillomacular retinoschisis associated with glaucoma].
Article
11 sectionsContents
- Classification
- Degenerative retinoschisis
- Hereditary retinoschisis
- Tractional retinoschisis
- Exudative retinoschisis
- Diagnosis
- Treatment
- Gene therapy
- Gene editing
- References
- External links
Retinoschisis is an eye disease characterized by the abnormal splitting of the retina's neurosensory layers, usually in the outer plexiform layer. Retinoschisis can be divided into degenerative forms which are very common and almost exclusively involve the peripheral retina and hereditary forms which are rare and involve the central retina and sometimes the peripheral retina. The degenerative forms are asymptomatic and involve the peripheral retina only and do not affect the visual acuity. Some rarer forms result in a loss of vision in the corresponding visual field.
Almost all cases are X-linked recessive and caused by a mutation in the retinoschisin gene (RS1).