RGS13

Also known as regulator of G protein signaling 13

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.

Gene data

RGS13

Name: regulator of G protein signaling 13
Type: protein-coding
Position: 192,636,061–192,660,311 (+)
Ensembl: ENSG00000127074
RefSeq RNA: NM_002927.5, NM_144766.3
RefSeq protein: NP_002918.1, NP_658912.1

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway

Molecular function

GTPase activity GTPase activity GTPase activator activity protein binding

Cellular component

nucleus cytosol plasma membrane plasma membrane cytoplasmic side of plasma membrane

Pathways

Signal Transduction Signal Transduction Signaling by GPCR Signaling by GPCR GPCR downstream signalling GPCR downstream signalling G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 13

Symbol: RGS13
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:192,636,061-192,660,311
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

2 sections

Contents

References
Further reading

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.

RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.

Excerpted from Wikipedia’s “RGS13” article, available under the CC BY-SA 4.0 licence.