RGS18

Name

regulator of G protein signaling 18

Type

protein-coding

Position

192,158,344–192,187,172 (+)

Aliases

RGS13

Ensembl

ENSG00000150681

RefSeq RNA

NM_130782.3, XM_054338213.1

RefSeq protein

NP_570138.1, XP_054194188.1

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 18

Symbol

RGS18

Biotype

Protein coding

Organism

Homo sapiens

Location

1:192,158,344-192,187,172

Strand

Forward (+)

Assembly

GRCh38