RGS18
Sign in to saveAlso known as RGS13, regulator of G-protein signaling 18, regulator of G protein signaling 18
Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.
In the Vinony graph
Vinony's link graph records 31 inbound references to RGS18, and connects out to Q180686, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 8 Wikipedia language editions.
Gene data
RGS18- Name
- regulator of G protein signaling 18
- Type
- protein-coding
- Position
- 192,158,344–192,187,172 (+)
- Aliases
- RGS13
- Ensembl
- ENSG00000150681
- RefSeq RNA
- NM_130782.3, XM_054338213.1
- RefSeq protein
- NP_570138.1, XP_054194188.1
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
regulator of G protein signaling 18
- Symbol
- RGS18
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:192,158,344-192,187,172
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RGS18 PDB 2dlv.png
Show 6 more facts
- HomoloGene ID
- 11281
- exact match
- identifiers.org/ncbigene/64407
- genomic end
- 192154945
- genomic start
- 192158462
- cytogenetic location
- 1q31.2
- Commons category
- Regulator of G-protein signaling 18, RGS18
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.
== Function ==
Excerpted from Wikipedia’s “RGS18” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0