RGS2
Sign in to saveAlso known as G0S8, regulator of G-protein signaling 2, regulator of G protein signaling 2
Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).
Gene data
RGS2- Name
- regulator of G protein signaling 2
- Type
- protein-coding
- Position
- 192,809,038–192,812,283 (+)
- Aliases
- G0S8
- Ensembl
- ENSG00000116741
- RefSeq RNA
- NM_002923.4
- RefSeq protein
- NP_002914.1
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
regulator of G protein signaling 2
- Symbol
- RGS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:192,809,038-192,812,283
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RGS2 PDB 2af0.png
Show 6 more facts
- HomoloGene ID
- 2192
- exact match
- identifiers.org/ncbigene/5997
- genomic end
- 192812275
- genomic start
- 192778169
- cytogenetic location
- 1q31.2
- Commons category
- Regulator of G-protein signaling 2, RGS2
via Wikidata · CC0
~3 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).
== Function == RGS2 is thought to have protective effects against myocardial hypertrophy as well as atrial arrhythmias. Increased stimulation of Gs coupled β1-adrenergic receptors and Gq coupled α1-adrenergic receptors in the heart can result in cardiac hypertrophy. In the case of Gq protein coupled receptor (GqPCR) mediated hypertrophy, Gαq will activate the intracellular affectors phospholipase Cβ and rho guanine nucleotide exchange factor to stimulate cell processes which lead to cardiomyocyte hypertrophy. RGS2 functions as a GTPase Activating Protein (GAP) which acts to increase the natural GTPase activity of the Gα subunit. By increasing the GTPase activity of the Gα subunit, RGS2 promotes GTP hydrolysis back to GDP, thus converting the Gα subunit back to its inactive state and reducing its signalling ability. Both GsPCR and GqPCR activation can contribute to cardiac hypertrophy via activation of MAP Kinases as well. RGS2 has been shown to decrease phosphorylation of those MAP kinases and therefore decrease their activation in response to Gαs signalling.