RGS3

Also known as C2PA, RGP3, regulator of G-protein signaling 3, regulator of G protein signaling 3

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.

Gene data

RGS3

Name: regulator of G protein signaling 3
Type: protein-coding
Position: 113,444,731–113,597,743 (+)
Aliases: C2PA, RGP3
Ensembl: ENSG00000138835
RefSeq RNA: NM_001276260.2, NM_001276261.2, NM_001276262.2, NM_001282922.2, NM_001282923.2
RefSeq protein: NP_001263189.1, NP_001263190.1, NP_001263191.1, NP_001269851.1, NP_001269852.1

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway

Molecular function

GTPase activity GTPase activity GTPase activator activity GTPase activator activity protein binding

Cellular component

nucleus nucleus nucleus cytoplasm cytoplasm cytosol plasma membrane plasma membrane

Pathways

Axon guidance - Homo sapiens (human)Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (q) signalling events G alpha (i) signalling events Myometrial relaxation and contraction pathways Calcium Regulation in the Cardiac Cell

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 3

Symbol: RGS3
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:113,444,731-113,597,743
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

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Contents

References
Further reading

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.

Excerpted from Wikipedia’s “RGS3” article, available under the CC BY-SA 4.0 licence.