RGS5

Also known as MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.

Gene data

RGS5

Name: regulator of G protein signaling 5
Type: protein-coding
Position: 163,111,121–163,321,791 (−)
Aliases: MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
Ensembl: ENSG00000143248
RefSeq RNA: NM_001195303.3, NM_001254748.2, NM_001254749.2, NM_001414472.1, NM_001414473.1
RefSeq protein: NP_001182232.1, NP_001241677.1, NP_001241678.1, NP_001401401.1, NP_001401402.1

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway negative regulation of vascular associated smooth muscle cell proliferation

Molecular function

GTPase activity GTPase activity GTPase activator activity GTPase activator activity protein binding

Cellular component

cytoplasm cytoplasm cytosol plasma membrane cytoplasmic side of plasma membrane membrane membrane

Pathways

Signal Transduction Signal Transduction Signaling by GPCR Signaling by GPCR GPCR downstream signalling GPCR downstream signalling G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events Myometrial relaxation and contraction pathways

via MyGene.info

Gene · Ensembl

regulator of G protein signaling 5

Symbol: RGS5
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:163,111,121-163,321,791
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein RGS5 PDB 2crp.png

Show 6 more facts

exact match: identifiers.org/ncbigene/8490
HomoloGene ID: 2682
cytogenetic location: 1q23.3
genomic start: 163214295
genomic end: 163291684
Commons category: Regulator of G-protein signaling 5, RGS5

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Further reading

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.