Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011].
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Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.
Members of the Regulator of G protein signaling (RGS) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the guanine nucleotide-binding G alpha subunit.[supplied by OMIM]
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