RNF43

Also known as RNF124, URCC, ring finger protein 43, SSPCS

Ring finger protein 43 is a protein that in humans is encoded by the RNF43 gene.

In the Vinony graph

Within Vinony's link graph, RNF43 is referenced by 8 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 17.

Its subject is documented across 6 Wikipedia language editions.

Gene data

RNF43

Name: ring finger protein 43
Type: protein-coding
Position: 58,353,671–58,417,735 (−)
Aliases: RNF124, SSPCS, URCC
Ensembl: ENSG00000108375
RefSeq RNA: NM_001305544.3, NM_001305545.2, NM_001437987.1, NM_001438820.1, NM_001438821.1
RefSeq protein: NP_001292473.1, NP_001292474.1, NP_001424916.1, NP_001425749.1, NP_001425750.1

The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].