RSPO3
Sign in to saveAlso known as CRISTIN1, PWTSR, THSD2, R-spondin 3
protein-coding gene in the species Homo sapiens
Gene data
RSPO3- Name
- R-spondin 3
- Type
- protein-coding
- Position
- 127,118,658–127,199,481 (+)
- Aliases
- CRISTIN1, PWTSR, THSD2
- Ensembl
- ENSG00000146374
- RefSeq RNA
- NM_032784.5, XM_017011378.1, XM_054356597.1
- RefSeq protein
- NP_116173.2, XP_016866867.1, XP_054212572.1
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
Pathways
Wnt signaling pathway - Homo sapiens (human)Signal TransductionSignaling by WNTTCF dependent signaling in response to WNTGeneric Transcription PathwayRegulation of FZD by ubiquitinationRNA Polymerase II TranscriptionGene expression (Transcription)Transcriptional regulation by RUNX1RUNX1 regulates transcription of genes involved in WNT signaling
via MyGene.info
Gene · Ensembl
R-spondin 3
- Symbol
- RSPO3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:127,118,658-127,199,481
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 12484
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/84870
- genomic end
- 127199481
- genomic start
- 127118671
- chromosome
- human chromosome 6
- cytogenetic location
- 6q22.33
Sources (4)
via Wikidata · CC0