RTN3

Name

reticulon 3

Type

protein-coding

Position

63,681,444–63,759,909 (+)

Aliases

ASYIP, HAP, NSPL2, NSPLII, RTN3-A1

Ensembl

ENSG00000133318

RefSeq RNA

NM_001265589.2, NM_001265590.2, NM_001265591.2, NM_006054.4, NM_201428.3

RefSeq protein

NP_001252518.1, NP_001252519.1, NP_001252520.1, NP_006045.1, NP_958831.1

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012].

via MyGene.info

Gene · Ensembl

reticulon 3

Symbol

RTN3

Biotype

Protein coding

Organism

Homo sapiens

Location

11:63,681,444-63,759,909

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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