RTN3
Sign in to saveAlso known as ASYIP, HAP, NSPL2, NSPLII, RTN3-A1, reticulon 3
Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.
In the Vinony graph
Within Vinony's link graph, RTN3 is referenced by 3 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 6 Wikipedia language editions.
Gene data
RTN3- Name
- reticulon 3
- Type
- protein-coding
- Position
- 63,681,444–63,759,909 (+)
- Aliases
- ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
- Ensembl
- ENSG00000133318
- RefSeq RNA
- NM_001265589.2, NM_001265590.2, NM_001265591.2, NM_006054.4, NM_201428.3
- RefSeq protein
- NP_001252518.1, NP_001252519.1, NP_001252520.1, NP_006045.1, NP_958831.1
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
reticulon 3
- Symbol
- RTN3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:63,681,444-63,759,909
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 24934
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10313
- chromosome
- human chromosome 11
- genomic start
- 63448918
- genomic end
- 63527363
- cytogenetic location
- 11q13.1
- expressed in
- amygdala
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.
The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM]
Excerpted from Wikipedia’s “RTN3” article, available under the CC BY-SA 4.0 licence.