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saccharopine

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EntityQ3132238· pop 15· linked from 104 articles

saccharopine

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Also known as epsilon-N-(L-Glutar-2-yl)-L-lysine, N-[(S)-5-Amino-5-carboxypentyl]-L-glutamic acid, L-Saccharopin, N6-(L-1,3-Dicarboxypropyl)-L-lysine, N-(5-Amino-5-carboxypentyl)-L-glutamic acid, (S)-N-(5-amino-5-carboxypentyl)-L-Glutamic acid, N(6)-(L-1,3-Dicarboxypropyl)-L-lysine, N-[(5S)-5-Amino-5-carboxypentyl]-L-Glutamic acid

Saccharopine is an intermediate in the metabolism of amino acid lysine. It is a precursor of lysine in the alpha-aminoadipate pathway which occurs in fungi and euglenids. In mammals and seed plants saccharopine is an intermediate in the degradation of lysine, formed by condensation of lysine and alpha-ketoglutarate.

Chemical data

Formula
C11H20N2O6
Molecular weight
276.29 g/mol
IUPAC name
(2S)-2-[[(5S)-5-amino-5-carboxypentyl]amino]pentanedioic acid
SMILES
C(CCN[C@@H](CCC(=O)O)C(=O)O)C[C@@H](C(=O)O)N
InChIKey
ZDGJAHTZVHVLOT-YUMQZZPRSA-N
XLogP
-5.5
Polar surface area
150 Ų
H-bond donors
5
H-bond acceptors
8
Formal charge
0

via PubChem

Wikidata facts

Mass
276.132
Show 5 more facts
found in taxon
Phaseolus vulgaris
chemical formula
C₁₁H₂₀N₂O₆
canonical SMILES
C(CCNC(CCC(=O)O)C(=O)O)CC(C(=O)O)N
isomeric SMILES
C(CCN[C@@H](CCC(=O)O)C(=O)O)C[C@@H](C(=O)O)N
subject has role
primary metabolite
Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Biochemical reactions
  • Pathology
  • History
  • See also
  • References

{{chembox | ImageFile = Saccharopine.svg | ImageFile_Ref = | ImageName = Stereo, skeletal formula of saccharopine ((2S)-2-{[(5S)-5-aminopentyl]amino}) | IUPACName = 2-[(5-Amino-5-carboxypentyl)amino]pentanedioic acid | Section1 = | Section2 = | Section3 = }}

Saccharopine is an intermediate in the metabolism of amino acid lysine. It is a precursor of lysine in the alpha-aminoadipate pathway which occurs in fungi and euglenids. In mammals and seed plants saccharopine is an intermediate in the degradation of lysine, formed by condensation of lysine and alpha-ketoglutarate.

Excerpted from Wikipedia’s “saccharopine” article, available under the CC BY-SA 4.0 licence.