Also known as (2S)-2-amino-5-oxopentanoic acid, L-glutamate gamma-semialdehyde, L-glutamate 5-semialdehyde, 5-oxo-L-norvaline, glutamate-semialdehyde, glutam-5-al
Glutamate-5-semialdehyde is a non-proteinogenic amino acid involved in both the biosynthesis and degradation of proline and arginine (via ornithine), as well as in the biosynthesis of antibiotics, such as carbapenems. It is synthesized by the reduction of glutamyl-5-phosphate by glutamate-5-semialdehyde dehydrogenase. In solution in water, the aldehyde is in chemical equilibrium with (S)-1-pyrroline-5-carboxylic acid and this is the form in which many of its biochemical reactions occur.
Glutamate-5-semialdehyde is a non-proteinogenic amino acid involved in both the biosynthesis and degradation of proline and arginine (via ornithine), as well as in the biosynthesis of antibiotics, such as carbapenems. It is synthesized by the reduction of glutamyl-5-phosphate by glutamate-5-semialdehyde dehydrogenase. In solution in water, the aldehyde is in chemical equilibrium with (S)-1-pyrroline-5-carboxylic acid and this is the form in which many of its biochemical reactions occur.
Reduction of glutamic acid semialdehyde with sodium borohydride gives hydroxyaminovaleric acid.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).