SATB1
Sign in to saveAlso known as DEFDA, SATB homeobox 1, KTZSL, DNA-binding protein SATB1/SATB2, SATB1/SATB2, IPR039673
SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene. It is a dimeric/tetrameric transcription factor with multiple DNA binding domains (CUT1, CUT2 and a Homeobox domain). SATB1 specifically binds to AT-rich DNA sequences with high unwinding propensity called base unpairing regions (BURs), containing matrix attachment regions (MARs).
Gene data
SATB1- Name
- SATB homeobox 1
- Type
- protein-coding
- Position
- 18,345,056–18,445,621 (−)
- Aliases
- DEFDA, DHDBV, KTZSL
- Ensembl
- ENSG00000182568
- RefSeq RNA
- NM_001131010.4, NM_001195470.3, NM_001322871.2, NM_001322872.2, NM_001322873.2
- RefSeq protein
- NP_001124482.1, NP_001182399.1, NP_001309800.1, NP_001309801.1, NP_001309802.1
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SATB homeobox 1
- Symbol
- SATB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:18,345,056-18,445,621
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- protein family
- Subclass of
- DNA-binding protein
- Image
- Protein SATB1 PDB 1yse.png
Show 8 more facts
- HomoloGene ID
- 2232
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6304
- genomic end
- 18487080
- genomic start
- 18345377
- chromosome
- human chromosome 3
- cytogenetic location
- 3p24.3
- Commons category
- DNA-binding protein SATB1
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Function
- Immune system
- Other tissues
- Structure
- Clinical significance
- Rare neurodevelopmental disorders
- Cancer
- Interactions
- References
- Further reading
SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene. It is a dimeric/tetrameric transcription factor with multiple DNA binding domains (CUT1, CUT2 and a Homeobox domain). SATB1 specifically binds to AT-rich DNA sequences with high unwinding propensity called base unpairing regions (BURs), containing matrix attachment regions (MARs).
== Function ==
Excerpted from Wikipedia’s “SATB1” article, available under the CC BY-SA 4.0 licence.