SMARCA5

Also known as ISWI, SNF2H, WCRF135, hISWI, hSNF2H, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.

Gene data

SMARCA5

Name: SNF2 related chromatin remodeling ATPase 5
Type: protein-coding
Position: 143,513,445–143,557,486 (+)
Aliases: ISWI, SNF2H, WCRF135, hISWI, hSNF2H
Ensembl: ENSG00000153147
RefSeq RNA: NM_003601.4, XM_047416323.1, XM_054351108.1
RefSeq protein: NP_003592.3, XP_047272279.1, XP_054207083.1

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

rDNA heterochromatin formation regulation of DNA replication DNA repair chromatin organization nucleosome assembly nucleosome assembly chromatin remodeling chromatin remodeling

Molecular function

DNA binding DNA binding DNA binding chromatin binding helicase activity protein binding ATP binding ATP binding

Cellular component

chromatin condensed chromosome fibrillar center nucleus nucleus nucleus nucleus nucleoplasm

Pathways

Cell Cycle Epigenetic regulation of gene expression Epigenetic regulation of gene expression NoRC negatively regulates rRNA expression Positive epigenetic regulation of rRNA expression B-WICH complex positively regulates rRNA expression Negative epigenetic regulation of rRNA expression DNA Double-Strand Break Repair Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks DNA Double Strand Break Response

via MyGene.info

Gene · Ensembl

SNF2 related chromatin remodeling ATPase 5

Symbol: SMARCA5
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:143,513,445-143,557,486
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 55764
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8467
genomic end: 144478639
genomic start: 143513702
chromosome: human chromosome 4
cytogenetic location: 4q31.21
expressed in: gonad

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.

== Function ==

Excerpted from Wikipedia’s “SMARCA5” article, available under the CC BY-SA 4.0 licence.