SCN10A

Also known as FEPS2, Nav1.8, PN3, SNS, hPN3, sodium voltage-gated channel alpha subunit 10

Nav1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene.

Gene data

SCN10A

Name: sodium voltage-gated channel alpha subunit 10
Type: protein-coding
Aliases: FEPS2, Nav1.8, PN3, SNS

The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].

via MyGene.info

Gene · Ensembl

sodium voltage-gated channel alpha subunit 10

Symbol: SCN10A
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:38,696,802-38,816,286
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 6 more facts

HomoloGene ID: 21300
exact match: identifiers.org/ncbigene/6336
genomic start: 38696802
genomic end: 38816286
cytogenetic location: 3p22.2
Commons category: Nav1.8

Sources (5)

via Wikidata · CC0

~9 min read

Article

10 sections

Contents

Function
Clinical significance
Pain signalling pathways
Suzetrigine
Brugada syndrome
Membrane trafficking
Painful peripheral neuropathies
References
Further reading
External links

Nav1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene.

Nav1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Nav1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages.