ANO1
Sign in to saveAlso known as DOG1, ORAOV2, TAOS2, TMEM16A, anoctamin 1
Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel.
Gene data
ANO1- Name
- anoctamin 1
- Type
- protein-coding
- Position
- 69,985,907–70,189,543 (+)
- Aliases
- DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A
- Ensembl
- ENSG00000131620
- RefSeq RNA
- NM_001378092.1, NM_001378093.1, NM_001378094.2, NM_001378095.2, NM_001378096.2
- RefSeq protein
- NP_001365021.1, NP_001365022.1, NP_001365023.1, NP_001365024.1, NP_001365025.1
Enables calcium activated cation channel activity; intracellular calcium activated chloride channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
anoctamin 1
- Symbol
- ANO1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:69,985,907-70,189,543
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 75079
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55107
- genomic end
- 70189530
- genomic start
- 69985907
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.3
- expressed in
- right coronary artery
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Structure
- Clinical significance
- References
- Further reading
- External links
Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel.
It is expressed in smooth muscle, epithelial cells, vomeronasal neurons, olfactory sustentacular cells, and is highly expressed in interstitial cells of Cajal (ICC) throughout the gastrointestinal tract.
Excerpted from Wikipedia’s “ANO1” article, available under the CC BY-SA 4.0 licence.