Structure via PubChem · Public domain (PubChem)
Chemical data
- Formula
- C20H22N2O7S
- Molecular weight
- 434.5 g/mol
- IUPAC name
- 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid
- SMILES
- CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
- InChIKey
- BTGNGJJLZOIYID-UHFFFAOYSA-N
- XLogP
- 3
- Polar surface area
- 147 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- heart disease, Sepsis
via ChEMBL · EBI
Research
555 papers- Sivelestat ameliorates sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway.International immunopharmacology · 2024
- Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice.Drug design, development and therapy · 2024
- Clinical Utility of the Sivelestat for the Treatment of ALI/ARDS: Moving on in the Controversy?Intensive care research · 2023
- Sivelestat for septic patients with acute respiratory distress syndrome: a systematic review and meta-analysis of a deadly duo.Frontiers in medicine · 2025
- Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis.Pharmaceutics · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 434.114772
- Has use
- medication
Show 3 more facts
- chemical formula
- C₂₀H₂₂N₂O₇S
- canonical SMILES
- CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
- Commons category
- Sivelestat
Sources (2)
via Wikidata · CC0
Article · Español
Sivelestat (nombre DCI ONO 5046, comercializado como Elaspol) es un inhibidor de la proteína humana y está siendo probada en el tratamiento de afecciones pulmonares como insuficiencia respiratoria y fibrosis pulmonar.
Abstract from DBpedia / Wikipedia · CC BY-SA