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GeneQ18031591· pop 5· linked from 20 articles

SNAI2

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Also known as SLUG, SLUGH1, SNAIL2, WS2D, snail family transcriptional repressor 2, SLUGH

Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes epithelial to mesenchymal transition, differentiation (e.g. in gastrulation), and migration of cells.

Gene data

SNAI2

Name: snail family transcriptional repressor 2
Type: protein-coding
Position: 48,917,284–48,921,740 (−)
Aliases: SLUG, SLUGH, SLUGH1, SNAIL2, WS2D
Ensembl: ENSG00000019549
RefSeq RNA: NM_003068.5
RefSeq protein: NP_003059.1

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II osteoblast differentiation osteoblast differentiation epithelial to mesenchymal transition epithelial to mesenchymal transition aortic valve morphogenesis aortic valve morphogenesis

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding protein binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytosol

Pathways

Hippo signaling pathway - Homo sapiens (human)Adherens junction - Homo sapiens (human)PIP3 activates AKT signaling PIP3 activates AKT signaling Developmental Biology Cell-Cell communication Signal Transduction Signal Transduction Adherens junctions interactions Cell-cell junction organization

via MyGene.info

Gene · Ensembl

snail family transcriptional repressor 2

Symbol: SNAI2
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:48,917,284-48,921,740
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

6 sections

Contents

Function
Clinical significance
Interactions
Snail2 and PRC2 in Neural Crest Development
References
Further reading

Zinc finger protein SNAI2 (also called SLUG) is a transcription factor that in humans is encoded by the SNAI2 gene. It promotes epithelial to mesenchymal transition, differentiation (e.g. in gastrulation), and migration of cells.

== Function ==

Excerpted from Wikipedia’s “SNAI2” article, available under the CC BY-SA 4.0 licence.

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