SOD2
Sign in to saveAlso known as IPOB, MNSOD, MVCD6, IPO-B, Mn-SOD, superoxide dismutase 2, mitochondrial, superoxide dismutase 2, GClnc1
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen p
Gene data
SOD2- Name
- superoxide dismutase 2
- Type
- protein-coding
- Position
- 159,569,593–159,762,529 (−)
- Aliases
- GC1, GClnc1, IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD, lncRNA-GC1
- Ensembl
- ENSG00000291237
- RefSeq RNA
- NM_000636.4, NM_001024465.3, NM_001024466.3, NM_001322814.2, NM_001322815.2
- RefSeq protein
- NP_000627.2, NP_001019636.1, NP_001019637.1, NP_001309743.1, NP_001309744.1
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Instance of
- gene
- Image
- Protein SOD2 PDB 1ap5.png
Show 7 more facts
- HomoloGene ID
- 530
- cytogenetic location
- 6q25.3
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6648
- chromosome
- human chromosome 6
- genomic start
- 160090089
- genomic end
- 160183561
via Wikidata · CC0
~12 min read
Encyclopedic overview
12 sectionsContents
- Structure
- Function
- Mechanism
- Clinical significance
- Cancer risk
- Role in oxidative stress
- Yeast studies
- Role in invertebrates
- Animal studies
- Interactions
- References
- Further reading
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. A related pseudogene has been identified on chromosome 1. Alternative splicing of this gene results in multiple transcript variants. This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
== Structure ==
Excerpted from Wikipedia’s “SOD2” article, available under the CC BY-SA 4.0 licence.