IYD

Name

iodotyrosine deiodinase

Type

protein-coding

Position

150,368,892–150,405,969 (+)

Aliases

C6orf71, DEHAL1, IYD-1, TDH4

Ensembl

ENSG00000009765

RefSeq RNA

NM_001164694.2, NM_001164695.2, NM_001318495.2, NM_203395.3, NR_134655.2

RefSeq protein

NP_001158166.1, NP_001158167.1, NP_001305424.1, NP_981932.1

This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

via MyGene.info

Gene · Ensembl

iodotyrosine deiodinase

Symbol

IYD

Biotype

Protein coding

Organism

Homo sapiens

Location

6:150,368,892-150,405,969

Strand

Forward (+)

Assembly

GRCh38