Squalene epoxidase
Sign in to saveAlso known as squalene monooxygenase, SE, SQLE
mammalian protein found in Homo sapiens
Protein · UniProt
Squalene monooxygenase
- Gene
- SQLE
- Organism
- Homo sapiens (Human)
- Length
- 574 aa
- Molecular mass
- 63,923 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis
3D-structureEndoplasmic reticulumFADFlavoproteinLipid metabolismMembraneMicrosomeOxidoreductase
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
886 papers- Targeting squalene epoxidase restores anti-PD-1 efficacy in metabolic dysfunction-associated steatohepatitis-induced hepatocellular carcinoma.Gut · 2024
- Squalene Epoxidase: Its Regulations and Links with Cancers.International journal of molecular sciences · 2024
- Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
- Squalene epoxidase as a promising metabolic target in cancer treatment.Cancer letters · 2018
- Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.Gut · 2022
via PubMed
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/Q14534
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0