Also known as ASV, SRC1, c-SRC, p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6
enzym
Gene data
SRC- Name
- SRC proto-oncogene, non-receptor tyrosine kinase
- Type
- protein-coding
- Position
- 37,344,673–37,406,050 (+)
- Aliases
- ASV, SRC1, THC6, c-SRC, p60-Src
- Ensembl
- ENSG00000197122
- RefSeq RNA
- NM_005417.5, NM_198291.3, XM_017028026.2, XM_047440396.1, XM_047440397.1
- RefSeq protein
- NP_005408.1, NP_938033.1, XP_016883515.1, XP_047296352.1, XP_047296353.1
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SRC proto-oncogene, non-receptor tyrosine kinase
- Symbol
- SRC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:37,344,673-37,406,050
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Article · Svenska
Proto-oncogene tyrosine-protein kinase Src eller Src är ett enzym som kodas av genen SRC.Src uttalas "Sark", eftersom det är en kortform av sarkom, en form av cancer. Enzymet aktiveras av ett annat enzym kallat FAK när celler binder till extracellulärt matrix, vilket initierar en signaltransduktionsväg som orsakar bland annat ökad celldelning och minskad apoptos. Föga förvånande är mutationer på Src eller Src-reglerande enzymer ofta onkogena, det vill säga ger upphov till cancerceller.
Abstract from DBpedia / Wikipedia · CC BY-SA