Synaptic vesicle glycoprotein 2A
Sign in to saveAlso known as SV2A
Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein belonging to a family of keratan sulfate proteoglycans, located on the synaptic vesicles of mammalian neuronal and endocrine cells. It is encoded by the SV2A gene.
Protein · UniProt
Synaptic vesicle glycoprotein 2A
- Gene
- SV2A
- Organism
- Homo sapiens (Human)
- Length
- 742 aa
- Molecular mass
- 82,695 Da
- Evidence
- 1: Evidence at protein level
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
2 registered- PHASE1/PHASE2COMPLETEDEffect of CT1812 Treatment on Brain Synaptic DensityCognition Therapeutics · NCT03493282
- NOT_YET_RECRUITINGSV2A-PET/CT and PET/MRI Combined Clinical Criteria Score in the Diagnosis of Early Cognitive AlterationAnhui Provincial Hospital · NCT06445582
Wikidata facts
- Instance of
- protein
Show 1 more fact
- found in taxon
- Homo sapiens
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Localisation
- SV2A PET
- See also
- References
- Further reading
- External links
Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein belonging to a family of keratan sulfate proteoglycans, located on the synaptic vesicles of mammalian neuronal and endocrine cells. It is encoded by the SV2A gene.
SV2A is the most widely expressed isoform of the SV2 family (which also includes the SV2B and SV2C proteins) found in all brain regions. The role of the SV2 proteins is not well understood; however, they are thought to be involved in regulating vesicular processes.
Excerpted from Wikipedia’s “Synaptic vesicle glycoprotein 2A” article, available under the CC BY-SA 4.0 licence.