Structure via PubChem · Public domain (PubChem)
synhexyl
Sign in to saveParahexyl, also known as synhexyl, is a synthetic homologue of tetrahydrocannabinol (THC) which was invented in 1941 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis.
Chemical data
- Formula
- C22H32O2
- Molecular weight
- 328.5 g/mol
- IUPAC name
- 3-hexyl-6,6,9-trimethyl-7,8,9,10-tetrahydrobenzo[c]chromen-1-ol
- SMILES
- CCCCCCC1=CC(=C2C3=C(CCC(C3)C)C(OC2=C1)(C)C)O
- InChIKey
- OORFXDSWECAQLI-UHFFFAOYSA-N
- XLogP
- 6.2
- Polar surface area
- 29.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 328.24
Show 2 more facts
- chemical formula
- C₂₂H₃₂O₂
- canonical SMILES
- CCCCCCC1=CC2=C(C3=C(CCC(C3)C)C(O2)(C)C)C(=C1)O
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
3 sectionsContents
- Isomerism
- See also
- References
Parahexyl, also known as synhexyl, is a synthetic homologue of tetrahydrocannabinol (THC) which was invented in 1941 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis.
Parahexyl is similar in both structure and activity to THC, differing only in the position of one double bond and the lengthening of the chain by one CH2 group to . Parahexyl produces effects typical of other cannabinoid receptor agonists in animals. It has a somewhat higher oral bioavailability than THC itself but is otherwise very similar. Presumably, it acts as a CB1 receptor agonist in the same way as THC, but as there has been no research published using parahexyl since the discovery of the CB1 receptor, this has not been definitively confirmed.
Excerpted from Wikipedia’s “synhexyl” article, available under the CC BY-SA 4.0 licence.
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