TCEA1
Sign in to saveAlso known as GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.
Gene data
TCEA1- Name
- transcription elongation factor A1
- Type
- protein-coding
- Position
- 53,966,552–54,022,508 (−)
- Aliases
- GTF2S, SII, TCEA, TF2S, TFIIS
- Ensembl
- ENSG00000187735
- RefSeq RNA
- NM_006756.4, NM_201437.3, NR_109901.2, NR_109902.2
- RefSeq protein
- NP_006747.1, NP_958845.1
Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
transcription elongation factor A1
- Symbol
- TCEA1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:53,966,552-54,022,508
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TCEA1 PDB 1tfi.png
Show 8 more facts
- HomoloGene ID
- 55984
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6917
- genomic end
- 54022456
- genomic start
- 54879112
- chromosome
- human chromosome 8
- cytogenetic location
- 8q11.23
- expressed in
- lactiferous duct
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.
In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex. A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.
Excerpted from Wikipedia’s “TCEA1” article, available under the CC BY-SA 4.0 licence.