TLE1
Sign in to saveAlso known as ESG, ESG1, GRG1, transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor, TLE-1
gene umano
Gene data
TLE1- Name
- TLE family member 1, transcriptional corepressor
- Type
- protein-coding
- Position
- 81,582,313–81,689,681 (−)
- Aliases
- ESG, ESG1, GRG1, TLE-1
- Ensembl
- ENSG00000196781
- RefSeq RNA
- NM_001303103.2, NM_001303104.2, NM_005077.5, XM_005252151.2, XM_005252152.2
- RefSeq protein
- NP_001290032.1, NP_001290033.1, NP_005068.2, XP_005252208.1, XP_005252209.1
Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
regulation of DNA-templated transcriptionsignal transductionanimal organ morphogenesispositive regulation of gene expressionnegative regulation of Wnt signaling pathwaynegative regulation of canonical NF-kappaB signal transductionnegative regulation of DNA-templated transcriptionnegative regulation of canonical Wnt signaling pathway
Molecular function
Pathways
Wnt signaling pathway - Homo sapiens (human)Notch signaling pathway - Homo sapiens (human)Cell-Cell communicationSignaling by NOTCHSignal TransductionSignal TransductionDegradation of beta-catenin by the destruction complexDegradation of beta-catenin by the destruction complexSignaling by WNTSignaling by WNT
via MyGene.info
Gene · Ensembl
TLE family member 1, transcriptional corepressor
- Symbol
- TLE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:81,582,313-81,689,681
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI