RUNX3

Also known as AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.

Gene data

RUNX3

Name: RUNX family transcription factor 3
Type: protein-coding
Position: 24,899,511–24,965,121 (−)
Aliases: AML2, CBFA3, PEBP2aC
Ensembl: ENSG00000020633
RefSeq RNA: NM_001031680.2, NM_001320672.1, NM_004350.3, XM_005246024.5, XM_011542351.2
RefSeq protein: NP_001026850.1, NP_001307601.1, NP_004341.1, XP_005246081.1, XP_011540653.1

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II ossification chondrocyte differentiation regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor binding

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Th1 and Th2 cell differentiation - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Developmental Biology Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Generic Transcription Pathway Generic Transcription Pathway Binding of TCF/LEF:CTNNB1 to target gene promoters

via MyGene.info

Gene · Ensembl

RUNX family transcription factor 3

Symbol: RUNX3
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:24,899,511-24,965,121
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein RUNX3 PDB 1cmo.png

Show 8 more facts

HomoloGene ID: 37914
chromosome: human chromosome 1
genetic association: Crohn's disease
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/864
genomic end: 25291612
genomic start: 25226002
cytogenetic location: 1p36.11

Sources (5)

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~4 min read

Encyclopedic overview

8 sections

Contents

Function
Knockout mouse
The RUNX3 controversy and resolution
Interactions
See also
References
Further reading
External links

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.

== Function ==

Excerpted from Wikipedia’s “RUNX3” article, available under the CC BY-SA 4.0 licence.

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RUNX3

Gene data

Gene Ontology

Pathways

Gene · Ensembl

Wikidata facts

Encyclopedic overview

Available in 5 languages

What links here822 pages

What links here822 pages