RUNX3
Sign in to saveAlso known as AML2, CBFA3, PEBP2aC, runt related transcription factor 3, RUNX family transcription factor 3
Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.
Gene data
RUNX3- Name
- RUNX family transcription factor 3
- Type
- protein-coding
- Aliases
- AML2, CBFA3, PEBP2aC
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
via MyGene.info
Wikidata facts
- Image
- Protein RUNX3 PDB 1cmo.png
Show 5 more facts
- HomoloGene ID
- 37914
- exact match
- identifiers.org/ncbigene/864
- genomic end
- 25291612
- genomic start
- 25226002
- cytogenetic location
- 1p36.11
via Wikidata · CC0
~4 min read
Article
8 sectionsContents
- Function
- Knockout mouse
- The RUNX3 controversy and resolution
- Interactions
- See also
- References
- Further reading
- External links
Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.
== Function ==