TLE2
Sign in to saveAlso known as ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.
Gene data
TLE2- Name
- TLE family member 2, transcriptional corepressor
- Type
- protein-coding
- Position
- 2,997,632–3,047,635 (−)
- Aliases
- ESG, ESG2, GRG2
- Ensembl
- ENSG00000065717
- RefSeq RNA
- NM_001144761.2, NM_001144762.2, NM_001300846.2, NM_003260.5, XM_006722864.3
- RefSeq protein
- NP_001138233.1, NP_001138234.1, NP_001287775.1, NP_003251.2, XP_006722927.1
Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
Wnt signaling pathway - Homo sapiens (human)Notch signaling pathway - Homo sapiens (human)Signaling by NOTCHSignal TransductionSignal TransductionDegradation of beta-catenin by the destruction complexDegradation of beta-catenin by the destruction complexSignaling by WNTSignaling by WNTSignaling by NOTCH1
via MyGene.info
Gene · Ensembl
TLE family member 2, transcriptional corepressor
- Symbol
- TLE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:2,997,632-3,047,635
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 20693
- exact match
- identifiers.org/ncbigene/7089
- genomic end
- 3047633
- genomic start
- 2997639
- cytogenetic location
- 19p13.3
Sources (4)
via Wikidata · CC0
Connections
Q180686
Entity
human chromosome 19
Entity
Ensembl genome database project
Entity
protein
Entity
Wikidata
Entity
gene
Entity
chromosome
Entity
digital object identifier
Entity
International Standard Serial Number
Entity
bibcode
Entity
human genome
Entity
Q229883
Entity
base pair
Entity
locus
Entity
gene expression
Entity
Online Mendelian Inheritance in Man
Entity
Q22908627
Entity
Entrez
Entity
Q905695
Entity
Handle System
Entity