TLE2
Sign in to saveAlso known as ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
gen van de soort Homo sapiens
Gene data
TLE2- Name
- TLE family member 2, transcriptional corepressor
- Type
- protein-coding
- Position
- 2,997,632–3,047,635 (−)
- Aliases
- ESG, ESG2, GRG2
- Ensembl
- ENSG00000065717
- RefSeq RNA
- NM_001144761.2, NM_001144762.2, NM_001300846.2, NM_003260.5, XM_006722864.3
- RefSeq protein
- NP_001138233.1, NP_001138234.1, NP_001287775.1, NP_003251.2, XP_006722927.1
Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
Wnt signaling pathway - Homo sapiens (human)Notch signaling pathway - Homo sapiens (human)Signaling by NOTCHSignal TransductionSignal TransductionDegradation of beta-catenin by the destruction complexDegradation of beta-catenin by the destruction complexSignaling by WNTSignaling by WNTSignaling by NOTCH1
via MyGene.info
Gene · Ensembl
TLE family member 2, transcriptional corepressor
- Symbol
- TLE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:2,997,632-3,047,635
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI