TOMM20

Also known as MAS20, MOM19, TOM20, translocase of outer mitochondrial membrane 20

Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. TOM20 is one of the receptor systems of the translocase of the outer membrane (TOM) complex in the outer mitochondrial membrane.

Gene data

TOMM20

Name: translocase of outer mitochondrial membrane 20
Type: protein-coding
Position: 235,109,337–235,128,962 (−)
Aliases: MAS20, MOM19, TOM20
Ensembl: ENSG00000173726
RefSeq RNA: NM_014765.3
RefSeq protein: NP_055580.1

Enables protein-transporting ATPase activity and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

protein targeting intracellular protein transport response to muscle activity tRNA import into mitochondrion protein import into mitochondrial matrix protein import into mitochondrial matrix protein import into mitochondrial matrix protein insertion into mitochondrial outer membrane

Molecular function

protein binding transmembrane protein transporter activity mitochondrial signal sequence receptor activity

Cellular component

mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial envelope mitochondrial outer membrane mitochondrial outer membrane mitochondrial outer membrane

Pathways

Mitochondrial protein import Macroautophagy Metabolism of proteins Mitophagy PINK1-PRKN Mediated Mitophagy Deubiquitination Ub-specific processing proteases Post-translational protein modification Protein localization Autophagy

via MyGene.info

Gene · Ensembl

translocase of outer mitochondrial membrane 20

Symbol: TOMM20
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:235,109,337-235,128,962
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein TOMM20 PDB 1om2.png

Show 8 more facts

HomoloGene ID: 44649
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9804
genomic end: 235128837
genomic start: 235109341
chromosome: human chromosome 1
cytogenetic location: 1q42.3
expressed in: pons

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
See also
References
Further reading

== Function == In mitochondrial protein import, TOM20 is closely associated with the pore-forming TOM40 complex and acts by recognizing and binding the N-terminal MTSs (matrix-targeting sequences), which form an amphipathic alpha helix and aid passage of the target proteins into the mitochondrial matrix.

Excerpted from Wikipedia’s “TOMM20” article, available under the CC BY-SA 4.0 licence.