TOMM22

Also known as 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22

Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene.

Gene data

TOMM22

Name: translocase of outer mitochondrial membrane 22
Type: protein-coding
Position: 38,681,924–38,685,421 (+)
Aliases: 1C9-2, MST065, MSTP065, TOM22
Ensembl: ENSG00000100216
RefSeq RNA: NM_020243.5
RefSeq protein: NP_064628.1

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

intracellular protein transport protein import into mitochondrial matrix protein import into mitochondrial matrix protein import into mitochondrial matrix protein insertion into mitochondrial outer membrane protein localization to mitochondrion

Molecular function

protein binding transmembrane protein transporter activity transmembrane protein transporter activity transmembrane protein transporter activity mitochondrion targeting sequence binding

Cellular component

mitochondrion mitochondrion mitochondrial outer membrane mitochondrial outer membrane mitochondrial outer membrane mitochondrial outer membrane translocase complex mitochondrial outer membrane translocase complex membrane

Pathways

Mitochondrial protein import Macroautophagy Mitophagy PINK1-PRKN Mediated Mitophagy Protein localization Autophagy Selective autophagy

via MyGene.info

Wikidata facts

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HomoloGene ID: 10638
genomic start: 38681957
exact match: identifiers.org/ncbigene/56993
genomic end: 39080818
cytogenetic location: 22q13.1

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Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene.

The protein encoded by this gene is an integral membrane protein of the outer mitochondrial membrane. The encoded protein interacts with TOMM20 and TOMM40, and with other proteins forms a complex – the translocase of the outer membrane, to import cytosolic preproteins into the mitochondrion.