TOMM70

Also known as TOMM70A, Tom70, translocase of outer mitochondrial membrane 70

Mitochondrial import receptor subunit TOM70, also known as translocase of outer mitochondrial membrane protein 70 is a protein that in humans is encoded by the TOMM70 gene.

Gene data

TOMM70

Name: translocase of outer mitochondrial membrane 70
Type: protein-coding
Position: 100,363,431–100,401,423 (−)
Aliases: TOMM70A, Tom70
Ensembl: ENSG00000154174
RefSeq RNA: NM_014820.5
RefSeq protein: NP_055635.3

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021].

Pathways

Mitochondrial protein import Macroautophagy Disease Innate Immune System Immune System DDX58/IFIH1-mediated induction of interferon-alpha/beta Metabolism of proteins Mitophagy PINK1-PRKN Mediated Mitophagy Infectious disease

via MyGene.info

Gene · Ensembl

translocase of outer mitochondrial membrane 70

Symbol: TOMM70
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:100,363,431-100,401,423
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

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HomoloGene ID: 40112
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9868
genomic end: 100401089
genomic start: 100082275
chromosome: human chromosome 3
cytogenetic location: 3q12.2
expressed in: middle temporal gyrus

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Encyclopedic overview

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Contents

See also
References
Further reading

Mitochondrial import receptor subunit TOM70, also known as translocase of outer mitochondrial membrane protein 70 is a protein that in humans is encoded by the TOMM70 gene.

The translocase of the outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM]

Excerpted from Wikipedia’s “TOMM70” article, available under the CC BY-SA 4.0 licence.